Transgenerational Epigenetics

Transgenerational Epigenetics

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Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversiesMaternal and paternal effects on offspring phenotype in the dung beetle Onthophagus taurus. Evolution 2000 ... Razin A. CpG methylation, chromatin structure and gene silencing-a three-way connection. Embo J ... Nat Genet 1999; 23:314a€“8. Rakyan VK ... Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronicanbsp;...

Title:Transgenerational Epigenetics
Author: Trygve Tollefsbol
Publisher:Elsevier - 2014-05-02

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